PHYSICAL EVALUATION OF MEFENAMIC ACID CAPLET LOGO AND BRANDED GENERIC

DOI:

https://doi.org/10.51887/jpfi.v9i1.799

Abstract

Mefenamic acid is one of the drugs of choice for analgesic, anti-inflammatory and antipyretic treatments. This drug is in the form of caplets, capsules and suspensions. The community still considers that drugs with branded generic names are more qualified than generic drugs with logos. This study aims to evaluate the physical properties of branded generic mefenamic acid caplets and branded generics in the Tampan District of Pekanbaru City. Sampling was carried out from 2 generic products bearing the logo (G1 and G2) and 2 branded generic products (M1 and M2). The results of the physical properties evaluation of mefenamic acid caplets obtained were weight diversity test with percent weight in the range of 98.017-101.491%; size uniformity test which has a thickness in the range of 0.440-0.545 cm and a diameter range of 0.682-0.828 cm; hardness test has a range of 8.8-11.1 kg/cm2; fragility test with a range of 0.024-0.316%; endurance test ranges from 0.008 to 0.200%; and disintegration time test which ranges from 3 minutes 58 seconds to 19 minutes 55 seconds. Based on the results of this study it can be concluded that the evaluation of the physical properties of generic mefenamic acid caplets with branded and generic branded brands has fulfilled the physical properties requirements listed in the Indonesian Pharmacopoeia Edition IV and V.

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References

Febriyenti dan Trisna, D. 2005. Membandingkan Mutu Tablet Siprofloksasin Merek dagang Generik Secara In Vitro. Jurnal Akademika, Volume 9 Nomor 1, Hal. 127-130.
Wibowo, A. 2009. Cerdas Memilih Obat dan Mengenali Penyakit. Jakarta: PT. Lingkar Pena Kreativa.
Sulistyaningrum, I. H., Djatmiko, M., dan Sugiyono. 2012. Uji Sifat Fisik dan Disolusi Tablet Isosorbid Dinitrat 5 mg Sediaan Generik dan Sediaan Dengan Nama Dagang yang Beredar di Pasaran. Majalah Farmasi dan Farmakologi. Volume 16 Nomor 1, Hal. 21-30.
Octavia, M. D., Fitriani dan Firmansyah. 2011. Perbandingan Mutu Tablet Ibuprofen Generik dan Merek Dagang. Jurnal Farmasi. Volume 3 Nomor 1, Hal. 36-40.
Wilmana, P. F. 2007. Farmakologi dan Terapi. Edisi V. Jakarta: Bagian Farmakologi Fakultas Kedokteran Universitas Indonesia.
Indrawati, T., dan Sari, N. K. 2010. Stabilitas Kaplet Asam Mefenamat Dengan Suhu Dan Kelembaban Ruang Penyimpanan Yang Berbeda. Makara Seri Kesehatan, Volume 14 Nomor 2, Hal. 75–80.
Nenti, D. 2016. Uji Disolusi Terbanding Kaplet Asam Mefenamat Generik Bermerek dan Generik Berlogo dengan Paten pada Media Dapar HCl pH 1,2 dan Dapar Fosfat pH 6,8 dengan Metode Spektrofotometri UV-Vis. Universitas Al-Ghifari Bandung. Skripsi : Bandung.
Kurniawan, D. W., dan Sulaiman, S. 2009. Teknologi Sediaan Farmasi. Yogyakarta: Graha Ilmu.
Anonim. 1979. Farmakope Indonesia. Edisi III. Jakarta: Departemen Kesehatan Republik Indonesia.
Anonim. 1995. Farmakope Indonesia. Edisi IV. Jakarta: Departemen Kesehatan Republik Indonesia.
Ansel, H. C. 2005. Pengantar Bentuk Sediaan Farmasi. Edisi IV. Jakarta: Penerbit Universitas Indonesia.
Lachman, L., Lieberman, H.A., dan Kanig, J.L. 1994. Teori dan Praktek Farmasi Industri II. Edisi III. Jakarta: UI Press.
Hadisoewignyo, L., dan Fudholi, A. 2016. Sediaan Solid. Yogyakarta: Pustaka Pelajar.
Siregar, C. J. P., dan Wikarsa, S. 2010. Teknologi Farmasi Sediaan Tablet Dasar-dasar Praktis. Jakarta: Penerbit Buku Kedokteran EGC.
Anonim. 2014. Farmakope Indonesia. Edisi V. Jakarta: Departemen Kesehatan Republik Indonesia.
Sulaiman, T.N.S. 2007. Teknologi & Formulasi Sediaan Tablet. Yogyakarta: Pustaka Laboratorium Teknologi Farmasi, Fakultas Farmasi, Universitas Gadjah Mada.
Voight, Rudolf. 1995. Buku Pelajaran Teknologi Farmasi. Yogyakarta: Gadjah Mada University Press.
Syukri, Y. 2018. Teknologi Sediaan Obat Dalam Bentuk Solid. Yogyakarta: Universitas Islam Indonesia Press.

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Published

14-09-2020

How to Cite

PHYSICAL EVALUATION OF MEFENAMIC ACID CAPLET LOGO AND BRANDED GENERIC. (2020). Jurnal Penelitian Farmasi Indonesia, 9(1), 27–30. https://doi.org/10.51887/jpfi.v9i1.799

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