Uji Efek Analgetik Infusa Daun Jeruk Nipis (Citrus aurantifolia (Christm.) Swing) terhadap Mencit Putih (Mus musculus L) Jantan yang Diinduksi Asam Asetat 1%

DOI:

https://doi.org/10.51887/jpfi.v9i1.795

Abstract

Research has been carried out on the analgesic effect of infusion of lime leaves (Citrus aurantifolia (Christm.) Swing) on male white mice (Mus musculus L) induced 1% acetic acid.The purpose of this study was to see the effect of analgesic effect of infusion of lime leaves (Citrus aurantifolia (Christm.) Swing) on male white mice (Mus musculus L) using the Writhing Test method. Experimental animals were divided into 5 groups. The negative control group was only given aquades, a positive control group of acetyl salicylate acid with a dose of 1.3 mg / 20g BB which was suspended with 1% Na CMC, the treatment group was given a lime leaf infusion (Citrus aurantifolia (Christm.) Swing) with a concentration of 5 %, 10% and 20%.The experimental animals were given oral preparations as much as 1% BB, 30 minutes after which each group was induced with 1% acetic acid as much as 0.1 ml ip. The data obtained is processed using two-way Analysis of Variance (ANOVA). The results showed that the infusion of lime leaves at concentrations of 10% and 20% (Citrus aurantifolia (Christm.) Swing) has analgesic effects on mice induced 1% acetic acid, .significantly different from negative controls (p<0.05) but not as strong as acetyl salicylate (positive control)

Keywords : Analgetic, infusion, lime leaves, acetic acid

Downloads

Download data is not yet available.

References

Anonim. 2014. Farmakope Indonesia. Edisi V. Dapartemen Kesehatan RI. Jakarta.

Ganiswarna, S. 1995. Farmakologi dan Terapi, Edisi IV.Bagian Farmakologi Fakultas Kedokteran Universitas Indonesia. Jakarta.

Clearinsyah, E.P.2016.Efek Analgesik Ekstrak Daun Jeruk Nipis (Citrus aurantifolia) pada Mencit (Mus musculus) Yang Diinduksikan Dengan Asam Asetat. Skripsi. UNTAD. Palu

Gunawan, S.G. 2008.Farmakologi dan Terapi.Edisi 5. Balai Penerbit FKUI. Jakarta.

Hariana, A. 2008.Tumbuhan Obat dan Khasiatnya Seri 1. Penerbit Penebar Swadaya. Jakarta.

Harmita dan Radji, M. 2008.Buku Ajar Analisis Hayati.Edisi III. Penerbit Buku Kedokteran EGC. Jakarta.

Marlyn, R. 2012. Uji Efek Analgetik Ekstrak Etanol 70% Bunga Mawar (Rosa chinensis jacq) Pada Mencit yang Diinduksi Asam Asetat.Skripsi. Universitas Indonesia. Jakarta.

Parmar. N. S. dan Prakash. S. 2006. Screening Methods in Pharmachology.Alpa Science International. Oxford.

Sherwood L. 2012. Anatomi dan fisiologi manusia dari sel ke sistem.EGC. Jakarta.

Vogel, H. 2002. Drug Discovery and Evaluation Pharmacological Assay, (second edition). New York: Springer Verlag Berlin Heidelberg.

Wahyuni, D. K. Ekasari, W. Witono, J. R. Purnobasuki, H. 2016. Toga Indonesia. Airlangga University Press. Surabaya

Downloads

Published

14-09-2020

How to Cite

Uji Efek Analgetik Infusa Daun Jeruk Nipis (Citrus aurantifolia (Christm.) Swing) terhadap Mencit Putih (Mus musculus L) Jantan yang Diinduksi Asam Asetat 1%. (2020). Jurnal Penelitian Farmasi Indonesia, 9(1), 12–20. https://doi.org/10.51887/jpfi.v9i1.795

Issue

Section

Articles